Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16673098 | 0.83 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2MAPK1GAA | |
| SCHEMBL11485415 | 0.80 | PPARG (0.46) | KDM4EALDH1A1SMN1; SMN2MAPK1CYP1A2 | |
| SCHEMBL1241143 | 0.77 | POLB (0.39) | KDM4EALDH1A1SMN1; SMN2GAACYP3A4 | |
| SCHEMBL17165885 | 0.77 | POLB (0.42) | KDM4EALDH1A1SMN1; SMN2GAACYP3A4 | |
| SCHEMBL15641972 | 0.77 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2MAPK1CYP3A4 | |
| SCHEMBL9736640 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2MAPK1GAA | |
| Hydrochloric Acid SCHEMBL22778178 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2MAPK1GAA | |
| SCHEMBL22778205 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2MAPK1GAA | |
| SCHEMBL29525638 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2MAPK1GAA | |
| SCHEMBL5424752 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2911656-B1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SA (FR) | 2020-12-02 | — | — | EP | disclosed |
| US-9446015-B2 | Quinone based nitric oxide donating compounds for ophthalmic use | NICOX SCIENCE IRELAND (IE) | 2016-09-20 | — | — | US | disclosed |
| US-20150283106-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX SA (FR) | 2015-10-08 | — | — | US | disclosed |
| EP-2911656-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | Nicox Science Ireland (IE) | 2015-09-02 | — | — | EP | disclosed |
| US-9079821-B2 | Quinone based nitric oxide donating compounds | NICOX SCIENCE IRELAND (IE) | 2015-07-14 | — | — | US | disclosed |
| US-9061962-B2 | Quinone based nitric oxide donating compounds | NICOX SCIENCE IRELAND (IE) | 2015-06-23 | — | — | US | disclosed |
| EP-2707354-B1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX SCIENCE IRELAND (IE) | 2015-04-29 | — | — | EP | disclosed |
| US-20140342998-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX S.A. (FR) | 2014-11-20 | — | — | US | disclosed |
| US-20140135389-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX SA (FR) | 2014-05-15 | — | — | US | disclosed |
| WO-2014063923-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NICOX S.A. (FR) | 2014-05-01 | — | — | WO | disclosed |
| EP-2722326-A1 | Quinone based nitric oxide donating compounds | NICOX S.A. (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2707354-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | Nicox S.A. (FR) | 2014-03-19 | — | — | EP | disclosed |
| WO-2013060673-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NICOX S.A. (FR) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150283106-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE | NOS1, NOS3, NOS2 | KDM4E 1772/4885ALDH1A1 265/4885SMN1; SMN2 4842/4885 |
| US-20140135389-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NOS2, NQO1, NOS1 | KDM4E 1828/4885ALDH1A1 339/4885SMN1; SMN2 1510/4885 |
| US-20140342998-A1 | QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS | NOS2, NQO1, NOS1 | KDM4E 1828/4885ALDH1A1 339/4885SMN1; SMN2 1510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.