Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5904743 | 0.78 | KDM4E (0.47) | HSD17B10NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11961408 | 0.78 | ALDH1A1 (0.50) | HSD17B10NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7020024 | 0.78 | KDM4E (0.47) | HSD17B10NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27847623 | 0.76 | KDM4E (0.46) | HSD17B10NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28677516 | 0.75 | RAB9A (0.65) | NPC1CYP1A2CYP2C9CYP2C19KDM4E | |
| SCHEMBL17874008 | 0.75 | RET (0.46) | HSD17B10NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15029059 | 0.74 | CA12 (0.49) | HSD17B10NPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2761387 | 0.74 | SMN1; SMN2 (0.50) | HSD17B10NPC1KDM4EALDH1A1MAPT | |
| SCHEMBL17874000 | 0.73 | KDM4E (0.47) | HSD17B10NPC1KDM4EALDH1A1MAPT | |
| SCHEMBL2766579 | 0.71 | SMN1; SMN2 (0.44) | HSD17B10NPC1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920616-B | Synthesis process of amidine compound | 南京师范大学 | 2024-04-05 | — | — | CN | disclosed |
| CN-114920616-A | Synthetic process of amidine compound | 南京师范大学 | 2022-08-19 | — | — | CN | disclosed |
| US-9242995-B2 | Isoxazolopyridine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |
| US-9242995-B2 | Isoxazolopyridine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |
| US-9242995-B2 | Isoxazolopyridine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |
| US-20150038502-A1 | ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-02-05 | — | — | US | disclosed |
| US-20150038502-A1 | ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-02-05 | — | — | US | disclosed |
| US-20150038502-A1 | ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-02-05 | — | — | US | disclosed |
| EP-2771346-A1 | ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2014-09-03 | — | — | EP | disclosed |
| WO-2013062858-A1 | ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |
| WO-2013062858-A1 | ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038502-A1 | ISOXAZOLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY5R | HSD17B10 2543/4885NPC1 1343/4885CYP1A2 1488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.