SCHEMBL1489632

SCHEMBL1489632

CCC(C(=O)O)c1ccccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNQ2 O43526 2/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
CASP1 P29466 1/20 0.45
CXCL8 P10145 1/20 0.43
ACP3 P15309 1/20 0.42
ALDH1A1 P00352 1/20 0.41
ADRB2 P07550 2/20 0.41
ADRB1 P08588 2/20 0.41
AOC3 Q16853 1/20 0.41
CACNA1G O43497 1/20 0.40
CACNA2D1 P54289 1/20 0.40
CACNA1B Q00975 1/20 0.40
CACNB1 Q02641 1/20 0.40
LMNA P02545 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CYP2D6 P10635 1/20 0.40
NFKB1 P19838 1/20 0.40
HIF1A Q16665 1/20 0.40
PTGFR P43088 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30821928 1.00 KCNQ2 (0.50) KCNQ2MEN1KMT2ACASP1CXCL8
SCHEMBL8833604 0.89 KCNQ2 (0.51) KCNQ2MEN1KMT2ACASP1ACP3
SCHEMBL20534707 0.86 MEN1 (0.48) KCNQ2MEN1KMT2ACASP1CXCL8
SCHEMBL6909558 0.86 MEN1 (0.63) KCNQ2MEN1KMT2ACXCL8ALDH1A1
SCHEMBL27935785 0.85 KCNQ2 (0.49) KCNQ2MEN1KMT2ACASP1ACP3
SCHEMBL9588027 0.85 KCNQ2 (0.49) KCNQ2MEN1KMT2ACASP1ACP3
SCHEMBL2032138 0.84 KCNQ2 (0.48) KCNQ2MEN1KMT2ACASP1CXCL8
SCHEMBL23886599 0.83 MEN1 (0.51) KCNQ2MEN1KMT2ACASP1CXCL8
SCHEMBL7812432 0.83 MEN1 (0.51) KCNQ2MEN1KMT2ACASP1CXCL8
SCHEMBL30370919 0.83 MEN1 (0.51) KCNQ2MEN1KMT2ACASP1CXCL8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2033635-A1 Short-chain fatty acid derivatives for treating pruritus Asan Laboratories Company (Cayman) Limited (CN) 2009-03-11 EP claimed
EP-1951813-A1 METHOD OF REDUCING THE STYRENE CONTENT OF A POLY (ARYLENE ETHER) POLYSTYRENE BLEND, AND ARTICLES COMPRISING THE RESULTING THERMOPLASTIC RESIN General Electric Company (US) 2008-08-06 EP claimed
US-20080107646-A1 Administering phenylbutyric acid derivative and pharmaceutically acceptable carrier Sunny Pharmtech Inc. (TW) 2008-05-08 US claimed
US-7314909-B2 Method of reducing the styrene content of a poly(arylene ether)/polystyrene blend, and articles comprising the resulting thermoplastic resin GENERAL ELECTRIC COMPANY (US) 2008-01-01 US claimed
US-20070264241-A1 Compounds for Enhanced Cancer Therapy ZGENE A/S (DK) 2007-11-15 US claimed
WO-2007047217-A1 METHOD OF REDUCING THE STYRENE CONTENT OF A POLY (ARYLENE ETHER) POLYSTYRENE BLEND, AND ARTICLES COMPRISING THE RESULTING THERMOPLASTIC RESIN GENERAL ELECTRIC COMPANY (US) 2007-04-26 WO claimed
US-20070083035-A1 Method of reducing the styrene content of a poly(arylene ether)/polystyrene blend, and articles comprising the resulting thermoplastic resin SABIC GLOBAL TECHNOLOGIES IP B.V. (NL) 2007-04-12 US claimed
WO-2005079849-A2 COMPOUNDS FOR ENHANCED CANCER THERAPY ZGENE A/S (DK) 2005-09-01 WO claimed
US-6403646-B1 ADMINISTERING PHENYLBUTYRIC ACID OR DERIVATIVES TO TREAT LIVER DISEASE AND EMPHYSEMA CAUSED BY PROTEASE INHIBITOR TYPE Z MUTATION; STIMULATES SECRETION WITHOUT INCREASING SYNTHESIS OF PROTEIN PERLMUTTER DAVID H (US) 2002-06-11 US claimed
US-5883124-A ADMINISTERING PHENYLACETIC ACID DERIVATIVE AND RETINOID TO TREAT TUMORS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1999-03-16 US claimed
US-5712307-A Methods of inducing the production of hemoglobin and treating pathologies associated with abnormal hemoglobin activity using phemylacetic acids and derivatives therof THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-01-27 US claimed
US-5710178-A ARYL- AND ARYLOXYALKANOIC ACIDS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-01-20 US claimed
US-5708025-A BY INDUCING PRODUCTION OF FETAL HEMOGLOBINS BY ADMINISTERING SPECIFIED ARYL ACIDS, DERIVATIVES, SALTS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-01-13 US claimed
US-5661179-A ADMINISTERING; TREATS NEUROBLASTOMA, MYELODYSPLASIA, NON-SMALL CELL LUNG CANCER, PROSTATE CANCER, MELANOMA, BRAIN TUMOR, KAPOSI'S SARCOMA, LYMPHOMA, LEUKEMIA, BREAST AND LUNG CANCER, OSTEOSARCOMA AND FIBROSARCOMA THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-08-26 US claimed
US-5654333-A THERAPY FOR ANEMIA, CANCER, AIDS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-08-05 US claimed
US-5635533-A ANTITUMOR AGENTS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-06-03 US claimed
US-5635532-A ADMINISTERING PHENYL OR NAPHTHYL ACETIC ACID DERIVATIVES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-06-03 US claimed
US-5605930-A ADMINISTERING PHENYLACETIC ACID AS AN INHIBITOR OF THE MEVALONATE PATHWAY THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-02-25 US claimed
US-5190946-A Piperazine compounds restore sensitivity to drug resistant cancer cells HOFFMANN-LA ROCHE INC. (US) 1993-03-02 US claimed
EP-0443569-A2 Diamine derivatives and their use in oncology F. HOFFMANN-LA ROCHE AG (CH) 1991-08-28 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070264241-A1 Compounds for Enhanced Cancer Therapy TYMP, BAD, NUDT1 KCNQ2 3243/4885MEN1 2022/4885KMT2A 395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.