Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 0.56 |
| ▸ | GFER | P55789 | 2/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ILK | Q13418 | 2/20 | 0.50 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26216604 | 0.75 | ILK (0.58) | APPGFERAXLNPC1RAB9A | |
| SCHEMBL2139108 | 0.75 | APP (0.71) | APPGFERAXLNPC1RAB9A | |
| SCHEMBL7005689 | 0.73 | GFER (0.61) | APPGFERAXLNPC1RAB9A | |
| SCHEMBL9255622 | 0.72 | GFER (0.66) | APPGFERAXLNPC1RAB9A | |
| SCHEMBL1977616 | 0.72 | APP (1.00) | APPGFERNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12207347 | 0.72 | APP (1.00) | APPGFERNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26745378 | 0.72 | APP (0.55) | APPGFERAXLNPC1RAB9A | |
| SCHEMBL4804599 | 0.72 | APP (0.82) | APPNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL15425178 | 0.72 | APP (0.82) | APPNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5637618 | 0.72 | RAB9A (0.53) | APPNPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013062966-A2 | NOVEL TRPV3 MODULATORS | ABBVIE INC. (US) | 2013-05-02 | — | — | WO | claimed |