Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8943463 | 0.84 | ABCB11 (0.45) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL5545298 | 0.82 | PARP1 (0.46) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL3622854 | 0.82 | PARP1 (0.47) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL7416478 | 0.82 | KDM4E (0.50) | KDM4EALDH1A1MAPTHPGDTSHR | |
| Ammonia Solution, Strong SCHEMBL17727872 | 0.81 | PARP1 (0.46) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL3829415 | 0.79 | KDM4E (0.44) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL40536 | 0.79 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL5685695 | 0.78 | MAPT (0.42) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL18426587 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL30742732 | 0.78 | MAPT (0.42) | KDM4EALDH1A1MAPTHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |