Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058303 | 0.94 | HTR1A (0.38) | HTR6HTR1AHTR1DHTR2AHTR7 | |
| SCHEMBL17057920 | 0.83 | MCHR1 (0.37) | HTR6HTR1AHTR1DHTR2AHTR7 | |
| SCHEMBL17058094 | 0.81 | ALDH1A1 (0.36) | HTR6HTR1AHTR1DHTR2AHTR7 | |
| SCHEMBL11944311 | 0.79 | ALDH1A1 (0.39) | HTR6HTR1AHTR2AHTR7SLC2A1 | |
| SCHEMBL17058117 | 0.78 | HTR1A (0.39) | HTR6HTR1AHTR1DHTR2AHTR7 | |
| SCHEMBL17058320 | 0.77 | LMNA (0.36) | HTR6HTR1AHTR1DHTR2AHTR7 | |
| SCHEMBL17057818 | 0.77 | HTR1A (0.36) | HTR6HTR1AHTR1DHTR2AHTR7 | |
| SCHEMBL17058068 | 0.77 | HTR1A (0.39) | HTR6HTR1AHTR1DHTR2AHTR7 | |
| SCHEMBL17057805 | 0.76 | CA12 (0.37) | SLC2A1SLC2A3MCHR1NPBWR1SMN1; SMN2 | |
| SCHEMBL11945607 | 0.76 | HTR1A (0.38) | HTR6HTR1AHTR1DHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |