Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14080970 | 0.76 | GRIA1 (0.40) | GRIA1GRIA2GRIA3GRIA4PSMB5 | |
| SCHEMBL6780467 | 0.73 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4BCHE | |
| SCHEMBL4929162 | 0.70 | GRIA1 (0.55) | GRIA1GRIA2GRIA3GRIA4PSMB5 | |
| SCHEMBL5816157 | 0.68 | GRIA1 (0.41) | GRIA1GRIA2GRIA3GRIA4BCHE | |
| SCHEMBL6783794 | 0.65 | GRIA1 (0.41) | GRIA1GRIA2GRIA3GRIA4BCHE | |
| SCHEMBL7039122 | 0.63 | NOTUM (0.46) | GRIA1GRIA2GRIA3GRIA4BCHE | |
| SCHEMBL2269074 | 0.63 | NUDT1 (0.46) | GRIA1GRIA2GRIA3GRIA4BCHE | |
| SCHEMBL29805885 | 0.63 | NUDT1 (0.46) | GRIA1GRIA2GRIA3GRIA4BCHE | |
| SCHEMBL3502666 | 0.62 | CHRNE (0.41) | GRIA1GRIA2GRIA3GRIA4PSMB5 | |
| SCHEMBL21187595 | 0.60 | GRIA1 (0.46) | GRIA1GRIA2GRIA3GRIA4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |