Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4131820 | 0.85 | NPBWR1 (0.45) | TP53NPBWR1MCHR1HTR6ADRB1 | |
| Hydrochloric Acid SCHEMBL4137286 | 0.84 | NPBWR1 (0.45) | TP53NPBWR1MCHR1HTR6ADRB1 | |
| SCHEMBL17057895 | 0.83 | RAB9A (0.44) | NPBWR1MCHR1 | |
| SCHEMBL14081477 | 0.83 | NPBWR1 (0.44) | TP53NPBWR1MCHR1HTR6ADRB1 | |
| SCHEMBL14899781 | 0.80 | NPBWR1 (0.35) | NPBWR1MCHR1HTR6 | |
| SCHEMBL14899875 | 0.80 | NPBWR1 (0.39) | TP53NPBWR1MCHR1HTR6 | |
| SCHEMBL14899899 | 0.78 | USP2 (0.35) | TP53MCHR1HTR6HTR1ASLC6A2 | |
| SCHEMBL11946412 | 0.74 | POLB (0.43) | TP53NPBWR1MCHR1HTR6ADRB1 | |
| SCHEMBL14081038 | 0.74 | TP53 (0.48) | TP53NPBWR1MCHR1 | |
| SCHEMBL17058001 | 0.74 | NPBWR1 (0.45) | TP53NPBWR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |