Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.40 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15945900 | 0.87 | OPRD1 (0.51) | OPRD1OPRK1NPC1ALDH1A1KDM4E | |
| SCHEMBL14902489 | 0.85 | ALDH1A1 (0.50) | OPRD1ALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL28089189 | 0.84 | NPC1 (0.52) | OPRD1NPC1ALDH1A1SIGMAR1CRHBP | |
| SCHEMBL14902486 | 0.83 | NPC1 (0.51) | OPRD1OPRK1NPC1ALDH1A1KDM4E | |
| SCHEMBL14905956 | 0.82 | NPC1 (0.54) | OPRD1NPC1ALDH1A1SIGMAR1 | |
| SCHEMBL14902487 | 0.81 | ALDH1A1 (0.60) | OPRD1OPRK1NPC1ALDH1A1KDM4E | |
| SCHEMBL14902500 | 0.80 | NPC1 (0.58) | NPC1ALDH1A1SIGMAR1 | |
| SCHEMBL14902532 | 0.79 | NPC1 (0.51) | NPC1ALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL14902491 | 0.79 | OPRD1 (0.50) | OPRD1OPRK1NPC1ALDH1A1KDM4E | |
| SCHEMBL14902534 | 0.79 | NPC1 (0.51) | NPC1ALDH1A1SIGMAR1NPFFR1NPFFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194747-A1 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INT (DE) | 2018-07-12 | — | — | US | disclosed |
| US-20180194747-A1 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INT (DE) | 2018-07-12 | — | — | US | disclosed |
| US-9920035-B2 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-03-20 | — | — | US | disclosed |
| US-9920035-B2 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-03-20 | — | — | US | disclosed |
| EP-2773633-B1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2017-08-02 | — | — | EP | disclosed |
| US-20150336933-A1 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INT (DE) | 2015-11-26 | — | — | US | disclosed |
| US-20150336933-A1 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INT (DE) | 2015-11-26 | — | — | US | disclosed |
| US-20140228374-A1 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
| US-20140228374-A1 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-14 | — | — | US | disclosed |
| US-8759349-B2 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-06-24 | — | — | US | disclosed |
| US-8759349-B2 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-06-24 | — | — | US | disclosed |
| WO-2013064450-A1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-10 | — | — | WO | disclosed |
| US-20130109697-A1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-02 | — | — | US | disclosed |
| US-20130109697-A1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194747-A1 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | SCNN1B, SCNN1A, TRPM5 | OPRD1 1101/4885OPRK1 681/4885NPC1 976/4885 |
| US-20130109697-A1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | SCNN1B, SCNN1A, TRPM5 | OPRD1 1101/4885OPRK1 681/4885NPC1 976/4885 |
| US-20140228374-A1 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | SCNN1B, SCNN1A, TRPM5 | OPRD1 1101/4885OPRK1 681/4885NPC1 976/4885 |
| US-20150336933-A1 | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof | SCNN1B, SCNN1A, TRPM5 | OPRD1 1101/4885OPRK1 681/4885NPC1 976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.