Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.51 |
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.49 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.49 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.47 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.47 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14905929 | 0.85 | PRMT6 (0.58) | ADORA1DOT1LP2RY12 | |
| SCHEMBL17921731 | 0.85 | PRMT6 (0.58) | ADORA1DOT1LP2RY12 | |
| SCHEMBL10885264 | 0.79 | ADORA2A (0.52) | ADORA3ADORA2AADORA2B | |
| SCHEMBL10887376 | 0.79 | ADORA2A (0.52) | ADORA3ADORA2AADORA2B | |
| SCHEMBL313413 | 0.78 | LMNA (0.72) | ADORA1ADORA3TP53SLC29A1TDP1 | |
| SCHEMBL19485512 | 0.78 | LMNA (0.72) | ADORA1ADORA3TP53SLC29A1TDP1 | |
| SCHEMBL233209 | 0.78 | LMNA (0.72) | ADORA1ADORA3TP53SLC29A1TDP1 | |
| SCHEMBL21953578 | 0.78 | LMNA (0.72) | ADORA1ADORA3TP53SLC29A1TDP1 | |
| SCHEMBL17889837 | 0.78 | LMNA (0.72) | ADORA1ADORA3TP53SLC29A1TDP1 | |
| SCHEMBL6909853 | 0.78 | LMNA (0.72) | ADORA1ADORA3TP53SLC29A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771343-B1 | METHYLTRANSFERASE INHIBITORS FOR TREATING CANCER | SLOAN KETTERING INST CANCER (US) | 2016-07-13 | — | — | EP | disclosed |
| WO-2013063417-A1 | METHYLTRANSFERASE INHIBITORS FOR TREATING CANCER | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2013-05-02 | — | — | WO | disclosed |