Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 4/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1490663 | 0.85 | HSD17B10 (0.44) | LCKGAAPOLBTGM2HPGD | |
| SCHEMBL30601557 | 0.79 | CYP3A4 (0.50) | SLC22A12LCKKDM4EGAAPTPN1 | |
| SCHEMBL3922933 | 0.79 | CYP3A4 (0.50) | SLC22A12LCKKDM4EGAAPTPN1 | |
| SCHEMBL1490631 | 0.77 | NPC1 (0.47) | KDM4EMEN1KMT2ACYP3A4HPGD | |
| SCHEMBL1490951 | 0.74 | MAPT (0.55) | KDM4EMEN1POLBKMT2AALDH1A1 | |
| SCHEMBL5241500 | 0.74 | GAA (0.50) | SLC22A12KDM4EGAAALOX5PTGS2 | |
| SCHEMBL5415882 | 0.74 | SLC22A12 (0.43) | SLC22A12LCKKDM4EALOX5PTGS2 | |
| SCHEMBL3927448 | 0.71 | GSK3B (0.47) | SLC22A12KDM4EPTPN1ALOX5PTGS2 | |
| SCHEMBL31426087 | 0.71 | GSK3B (0.47) | SLC22A12KDM4EPTPN1ALOX5PTGS2 | |
| SCHEMBL31426090 | 0.71 | GSK3B (0.47) | SLC22A12KDM4EPTPN1ALOX5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477698-A2 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | Centre National de la Recherche Scientifique (FR) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011033115-A2 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-03-24 | — | — | WO | disclosed |