Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1490951 | 0.84 | MAPT (0.55) | RAB9AMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL30938830 | 0.83 | MAPT (0.57) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL1490644 | 0.77 | SLC22A12 (0.38) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL1490910 | 0.77 | CES2 (0.52) | RAB9AHPGDALDH1A1HSD17B10KDM4E | |
| SCHEMBL28093168 | 0.76 | RAB9A (0.71) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL29445806 | 0.74 | ALDH1A1 (0.72) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL128781 | 0.74 | CA1 (0.61) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL6856233 | 0.74 | NPC1 (0.58) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL29431885 | 0.74 | CA1 (0.61) | NPC1RAB9AHPGDMEN1KMT2A | |
| SCHEMBL312754 | 0.74 | ALDH1A1 (0.72) | NPC1RAB9AHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477698-A2 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | Centre National de la Recherche Scientifique (FR) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011033115-A2 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-03-24 | — | — | WO | disclosed |