Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | JUN | P05412 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1490631 | 0.84 | NPC1 (0.47) | MAPTHTTALDH1A1MEN1KMT2A | |
| SCHEMBL6350154 | 0.83 | ABCG2 (0.67) | MAPTHTTNPSR1ABCG2ALDH1A1 | |
| SCHEMBL6257711 | 0.79 | CA12 (0.53) | MAPTHTTABCG2ALDH1A1RAB9A | |
| SCHEMBL16952190 | 0.77 | MAPT (0.53) | MAPTHTTNPSR1ABCG2ALDH1A1 | |
| SCHEMBL1490910 | 0.77 | CES2 (0.52) | MAPTALDH1A1KDM4ERAB9A | |
| SCHEMBL1759671 | 0.76 | MAPT (0.66) | MAPTHTTNPSR1ABCG2ALDH1A1 | |
| SCHEMBL12228747 | 0.76 | MAPT (0.82) | MAPTHTTNPSR1ABCG2ALDH1A1 | |
| SCHEMBL16062219 | 0.76 | PIN1 (0.39) | MAPTHTTALDH1A1POLBMEN1 | |
| SCHEMBL31167603 | 0.75 | ABCG2 (0.79) | MAPTHTTNPSR1ABCG2ALDH1A1 | |
| SCHEMBL28556103 | 0.75 | MAPT (0.64) | MAPTHTTNPSR1ABCG2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477698-A2 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | Centre National de la Recherche Scientifique (FR) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011033115-A2 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-03-24 | — | — | WO | disclosed |