SCHEMBL14907431

SCHEMBL14907431

C=CC(=O)OCCCOc1ccc2cc(C#Cc3ccc(C#N)cc3)ccc2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.45
MAPT P10636 2/20 0.41
ALDH1A1 P00352 2/20 0.41
MMP2 P08253 5/20 0.40
PPARD Q03181 1/20 0.40
PPARA Q07869 1/20 0.40
MMP3 P08254 6/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC2 Q92769 1/20 0.39
TSHR P16473 2/20 0.38
HPGD P15428 1/20 0.38
MMP1 P03956 1/20 0.38
MMP9 P14780 1/20 0.38
MMP13 P45452 1/20 0.38
CYP3A4 P08684 1/20 0.38
SLC6A2 P23975 4/20 0.38
SLC6A4 P31645 4/20 0.38
SLC6A3 Q01959 2/20 0.38
HTR3A P46098 1/20 0.36
KCNH2 Q12809 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12437039 0.94 THRB (0.50) THRBALDH1A1PPARDPPARAHDAC1
SCHEMBL19821125 0.89 THRB (0.52) THRBALDH1A1TSHRHPGDCYP3A4
SCHEMBL15852959 0.88 ALDH1A1 (0.41) THRBMAPTALDH1A1MMP2MMP3
SCHEMBL12437000 0.88 THRB (0.45) THRBALDH1A1TSHRHPGDCYP3A4
SCHEMBL14907509 0.88 THRB (0.45) THRBALDH1A1PPARATSHRHPGD
SCHEMBL14907503 0.87 THRB (0.46) THRBALDH1A1TSHRHPGDCYP3A4
SCHEMBL14302569 0.86 THRB (0.45) THRBALDH1A1HDAC1HDAC2TSHR
SCHEMBL12437036 0.85 THRB (0.42) THRBMAPTALDH1A1TSHRHPGD
SCHEMBL19789518 0.85 THRB (0.42) THRBALDH1A1TSHRHPGDCYP3A4
SCHEMBL2241855 0.85 THRB (0.56) THRBMAPTALDH1A1MMP2MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2771735-B1 SWITCH ELEMENT COMPRISING A LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2018-01-24 EP disclosed
US-9507185-B2 Switch element comprising a liquid crystalline medium MERCK PATENT GMBH (DE) 2016-11-29 US disclosed
US-9507185-B2 Switch element comprising a liquid crystalline medium MERCK PATENT GMBH (DE) 2016-11-29 US disclosed
US-20140293174-A1 SWITCH ELEMENT COMPRISING A LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2014-10-02 US disclosed
US-20140293174-A1 SWITCH ELEMENT COMPRISING A LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2014-10-02 US disclosed
WO-2013060406-A1 SWITCH ELEMENT COMPRISING A LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2013-05-02 WO disclosed