Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5961872 | 0.93 | HTT (0.48) | LMNAPOLBSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL19789599 | 0.92 | KMT2A (0.42) | LMNAPOLBSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL14907480 | 0.91 | POLB (0.52) | LMNAPOLBSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL16133504 | 0.90 | NPC1 (0.51) | LMNAPOLBSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL803172 | 0.86 | TDP1 (0.56) | LMNAPOLBSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL11986168 | 0.85 | MAPT (0.38) | LMNAPOLBMAPK1TDP1MAPT | |
| SCHEMBL22435487 | 0.85 | LMNA (0.48) | LMNASMN1; SMN2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL19160219 | 0.84 | TSHR (0.41) | LMNAPOLBSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL14088561 | 0.84 | POLB (0.41) | LMNAPOLBSMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL15062158 | 0.84 | TDP1 (0.54) | LMNAPOLBSMN1; SMN2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013060406-A1 | SWITCH ELEMENT COMPRISING A LIQUID CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2013-05-02 | — | — | WO | disclosed |