Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8584156 | 0.75 | AR (0.33) | ALDH1A1HTTKDM4EGAASMN1; SMN2 | |
| SCHEMBL14841950 | 0.71 | ALDH1A1 (0.39) | ALDH1A1HTTNPSR1HTR1AHTR2A | |
| SCHEMBL29824 | 0.71 | AR (0.32) | LMNA | |
| SCHEMBL28095748 | 0.70 | SPR (0.38) | ALDH1A1HTTNPSR1HTR1AHTR2A | |
| SCHEMBL3455163 | 0.70 | AVPR2 (0.32) | — | |
| SCHEMBL31555255 | 0.69 | AVPR1A (0.35) | ALDH1A1HTTNPSR1HTR1AHTR2A | |
| SCHEMBL28095772 | 0.65 | KCNQ2 (0.38) | ALDH1A1HTTNPSR1HTR1AHTR2A | |
| SCHEMBL1083195 | 0.62 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL24426630 | 0.61 | ELANE (0.33) | ALDH1A1NPSR1KDM4EGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL25261707 | 0.61 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588480-A2 | 3,4-DIHYDROPYRROLO[1,2-A]PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF& xA; | SANOFI (FR) | 2013-05-08 | — | — | EP | disclosed |