Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23387 | 0.85 | NOTUM (0.33) | — | |
| SCHEMBL14845189 | 0.77 | HSD17B10 (0.31) | — | |
| SCHEMBL8584156 | 0.75 | AR (0.33) | ARELANE | |
| SCHEMBL15562802 | 0.72 | FFAR1 (0.35) | — | |
| SCHEMBL14911074 | 0.71 | ALDH1A1 (0.33) | LMNA | |
| SCHEMBL19067224 | 0.69 | HTR2A (0.42) | — | |
| SCHEMBL4238187 | 0.64 | SLC6A4 (0.50) | — | |
| SCHEMBL21360355 | 0.64 | SLC6A4 (0.50) | — | |
| SCHEMBL20140984 | 0.64 | SLC6A4 (0.50) | — | |
| SCHEMBL1083195 | 0.62 | ALDH1A1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588480-A2 | 3,4-DIHYDROPYRROLO[1,2-A]PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF& xA; | SANOFI (FR) | 2013-05-08 | — | — | EP | disclosed |
| WO-2011161537-A2 | 3,4-DIHYDROPYRROLO[1,2-A]PYRAZINE-2,8(1H)-DICARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-29 | — | — | WO | disclosed |