Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | PARL | Q9H300 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6150295 | 1.00 | CA1 (0.38) | CA1CA9CA12ALDH1A1PKM | |
| Oxalic Acid SCHEMBL9728851 | 0.91 | CA12 (0.37) | CA1CA9CA12ALDH1A1PKM | |
| SCHEMBL338264 | 0.90 | KDM4E (0.34) | CA1CA9CA12ALDH1A1KDM4E | |
| SCHEMBL785147 | 0.90 | — | — | |
| SCHEMBL1123 | 0.90 | — | — | |
| SCHEMBL6742810 | 0.88 | CA12 (0.35) | CA1CA9CA12ALDH1A1PKM | |
| Acetic Acid SCHEMBL21834859 | 0.88 | FFAR3 (0.39) | CA1CA9CA12ALDH1A1PKM | |
| Acetic Acid SCHEMBL482738 | 0.88 | FFAR3 (0.39) | CA1CA9CA12ALDH1A1PKM | |
| Carbamic Acid SCHEMBL699756 | 0.88 | ACHE (0.39) | CA1CA9CA12ALDH1A1PKM | |
| SCHEMBL25175816 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114438047-B | Method for preparing polyethylene glycol modified urate oxidase | 重庆派金生物科技有限公司 | 2024-11-22 | — | — | CN | claimed |
| CN-114438048-B | Urate oxidase preparation and application thereof | 重庆派金生物科技有限公司 | 2024-10-22 | — | — | CN | claimed |
| CN-118497161-A | Polyethylene glycol modified urate oxidase | 重庆派金生物科技有限公司 | 2024-08-16 | — | — | CN | claimed |
| CN-118453890-A | Composition for improving stability of polyethylene glycol asparaginase, pharmaceutical composition and application thereof | 重庆派金生物科技有限公司 | 2024-08-09 | — | — | CN | claimed |
| CN-117866929-A | Pegylated arginine deiminase dimer preparation and use thereof | 重庆派金生物科技有限公司 | 2024-04-12 | — | — | CN | claimed |
| CN-116966279-A | Covalently modified recombinant phenylalanine lyase enteric-coated preparation and application thereof | 重庆派金生物科技有限公司 | 2023-10-31 | — | — | CN | claimed |
| CN-115869456-A | Preparation of in-situ gelation anti-swelling enhanced tissue adhesive material | 上海其胜生物制剂有限公司 | 2023-03-31 | — | — | CN | claimed |
| CN-114805540-A | Long-acting adrenomedullin derivative | 国立大学法人宫崎大学 | 2022-07-29 | — | — | CN | claimed |
| WO-2022095973-A1 | URATE OXIDASE PREPARATION AND USE THEREOF | 杭州远大生物制药有限公司 | 2022-05-12 | — | — | WO | claimed |
| WO-2022095974-A1 | METHOD FOR PREPARING POLYETHYLENE GLYCOL-MODIFIED URATE OXIDASE | 杭州远大生物制药有限公司 | 2022-05-12 | — | — | WO | claimed |
| CN-114438047-A | Method for preparing polyethylene glycol modified urate oxidase | 重庆派金生物科技有限公司 | 2022-05-06 | — | — | CN | claimed |
| CN-114438048-A | Urate oxidase preparation and application thereof | 重庆派金生物科技有限公司 | 2022-05-06 | — | — | CN | claimed |
| WO-2020228618-A1 | POLYETHYLENE GLYCOL-MODIFIED URATE OXIDASE | 重庆派金生物科技有限公司 | 2020-11-19 | — | — | WO | claimed |
| CN-111909906-A | Urate oxidase modified by polyethylene glycol | 重庆派金生物科技有限公司 | 2020-11-10 | — | — | CN | claimed |
| US-20030114647-A1 | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules | SHEARWATER CORPORATION | 2003-06-19 | — | — | US | claimed |
| US-20010007765-A1 | MULTI-ARMED, MONOFUNCTIONAL, AND HYDROLYTICALLY STABLE DERIVATIVES OF POLY (ETHYLENE GLYCOL) AND RELATED POLYMERS FOR MODIFICATION OF SURFACES AND MOLECULES | NEKTAR THERAPEUTICS | 2001-07-12 | — | — | US | claimed |
| JP-6340603-A | — | — | None | — | — | JP | disclosed |
| US-12544491-B2 | In situ forming hemostatic foam implants | ARSENAL MEDICAL, INC. (US) | 2026-02-10 | — | — | US | disclosed |
| EP-0094815-A2 | Oligopeptide prodrugs | SMITHKLINE BECKMAN CORPORATION (US) | 1983-11-23 | — | — | EP | disclosed |
| US-3965089-A | Process for the production of a cyclic ureido-derivative of a deoxystreptamine-containing antibiotic and products thereof | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JA) | 1976-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12544491-B2 | In situ forming hemostatic foam implants | F9, F12, F2 | CA1 2365/4885CA9 1594/4885CA12 1035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.