Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917462 | 0.85 | MKNK1 (0.49) | CHEK2MKNK1MKNK2IKBKB | |
| SCHEMBL27893425 | 0.83 | CYP3A4 (0.51) | CHEK2MKNK1MKNK2HSP90AA1HSP90AB1 | |
| SCHEMBL14917440 | 0.82 | CHEK2 (0.49) | CHEK2MKNK1MKNK2IKBKBALDH1A1 | |
| SCHEMBL27945205 | 0.80 | MKNK1 (0.47) | CHEK2MKNK1MKNK2HSP90AA1HSP90AB1 | |
| SCHEMBL17565133 | 0.78 | CYP2A6 (0.50) | CHEK2MKNK1MKNK2HSP90AA1HSP90AB1 | |
| SCHEMBL28079297 | 0.77 | MKNK1 (0.44) | CHEK2MKNK1MKNK2IKBKBF7 | |
| SCHEMBL14917433 | 0.77 | MKNK1 (0.50) | CHEK2MKNK1MKNK2HSP90AA1HSP90AB1 | |
| SCHEMBL972625 | 0.77 | NUDT1 (0.53) | CHEK2MKNK1MKNK2HSP90AA1HSP90AB1 | |
| SCHEMBL14917451 | 0.77 | CHEK2 (0.48) | CHEK2MKNK1MKNK2HSP90AA1HSP90AB1 | |
| SCHEMBL2572631 | 0.76 | MKNK1 (0.56) | CHEK2MKNK1MKNK2IKBKBF7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895585-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8809371-B2 | — | — | 2014-08-19 | — | — | US | disclosed |
| US-8772320-B2 | — | — | 2014-07-08 | — | — | US | disclosed |
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | SYK, CD38, BTK | CHEK2 2661/4885MKNK1 2094/4885MKNK2 1846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.