Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | CCNC | P24863 | 7/20 | 0.46 |
| ▸ | CDK8 | P49336 | 7/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | CHUK | O15111 | 4/20 | 0.43 |
| ▸ | IKBKB | O14920 | 3/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.43 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.43 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917462 | 0.86 | MKNK1 (0.49) | CHEK2MKNK1MKNK2CHUKIKBKB | |
| SCHEMBL14917436 | 0.82 | CHEK2 (0.52) | CHEK2MKNK1MKNK2IKBKBALDH1A1 | |
| SCHEMBL31119750 | 0.81 | CCNC (0.53) | CHEK2CCNCCDK8MKNK1MKNK2 | |
| SCHEMBL16713266 | 0.79 | ADORA2B (0.37) | CHEK2MKNK1MKNK2SRCBRAF | |
| SCHEMBL31032080 | 0.78 | CCNC (0.49) | CHEK2CCNCCDK8CHUKIKBKB | |
| SCHEMBL28762798 | 0.77 | TOP2A (0.51) | CHEK2MKNK1MKNK2KDRALDH1A1 | |
| SCHEMBL29695023 | 0.74 | CCNC (0.43) | CHEK2CCNCCDK8CHUKIKBKB | |
| SCHEMBL30859029 | 0.74 | ADORA2A (0.46) | CHEK2CCNCCDK8CHUKIKBKB | |
| SCHEMBL19138010 | 0.74 | NAPRT (0.46) | CHEK2MKNK1MKNK2KDRPRKCI | |
| SCHEMBL15380562 | 0.74 | MKNK1 (0.44) | CHEK2MKNK1MKNK2CDC7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | SYK, CD38, BTK | CHEK2 2661/4885CCNC 3266/4885CDK8 2386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.