Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 8/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17565133 | 0.84 | CYP2A6 (0.50) | NUDT1CYP2A6CYP3A4CYP2E1CYP2D6 | |
| SCHEMBL10199363 | 0.84 | CYP2A6 (0.50) | NUDT1CYP2A6CYP3A4CYP2E1CYP2D6 | |
| SCHEMBL15865503 | 0.81 | NOS3 (0.54) | TDO2HSP90AA1PTK2ALDH1A1NOS3 | |
| SCHEMBL3949315 | 0.79 | MAP4K4 (0.59) | NUDT1CYP2A6CYP3A4CYP2E1CYP2D6 | |
| SCHEMBL29576461 | 0.79 | MAP4K4 (0.59) | NUDT1CYP2A6CYP3A4CYP2E1CYP2D6 | |
| SCHEMBL945364 | 0.79 | IKBKB (0.52) | NUDT1CYP2A6CYP3A4CYP2C19HSP90AA1 | |
| SCHEMBL21540038 | 0.78 | NUDT1 (0.45) | NUDT1CYP2A6CYP3A4CYP2E1CYP2D6 | |
| SCHEMBL14917436 | 0.77 | CHEK2 (0.52) | NUDT1CYP2A6CYP3A4CYP2C19TDO2 | |
| SCHEMBL27586450 | 0.75 | NUDT1 (0.49) | NUDT1CYP2A6CYP3A4CYP2E1CYP2D6 | |
| SCHEMBL21742825 | 0.74 | PTGS2 (0.54) | CYP2A6CYP3A4CYP2E1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868177-B2 | Multi-cyclic compounds and method of use | AMGEN INC. (US) | 2011-01-11 | — | — | US | disclosed |
| US-20070213325-A1 | Multi-cyclic compound and method of use | AMGEN INC. (US) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213325-A1 | Multi-cyclic compound and method of use | TIE1, CDK1, CCNB1 | NUDT1 4102/4885CYP2A6 3190/4885CYP3A4 1966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.