Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | KDM4B | O94953 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22688908 | 0.83 | NAPRT (0.48) | HSD17B10HTTSMN1; SMN2NAPRTKDM4B | |
| SCHEMBL7718372 | 0.81 | KDM4E (0.43) | MKNK1MKNK2NNMTSMN1; SMN2CSNK2A1 | |
| SCHEMBL29275431 | 0.81 | HSD17B10 (0.40) | MKNK1MKNK2HSD17B10HTTNNMT | |
| SCHEMBL1058104 | 0.79 | HTT (0.39) | MKNK1MKNK2HSD17B10HTTNNMT | |
| SCHEMBL14917427 | 0.79 | NOS2 (0.52) | MKNK1MKNK2NAPRTSIRT3LIMK1 | |
| SCHEMBL14917426 | 0.79 | MKNK1 (0.41) | MKNK1MKNK2HSD17B10HTTNNMT | |
| SCHEMBL7655168 | 0.76 | PIK3C3 (0.38) | HSD17B10HTTNAPRTNOS3NOS2 | |
| SCHEMBL14917466 | 0.76 | NOS2 (0.43) | MKNK1MKNK2NAPRTPIK3CBNOS3 | |
| SCHEMBL27610033 | 0.76 | ALDH1A1 (0.46) | HSD17B10HTTROCK1KDM5CMAPT | |
| SCHEMBL17490709 | 0.75 | IKBKB (0.50) | NNMTCHEK2POLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303563-A1 | TREATMENT OF PERITONEAL INJURY USING JAK INHIBITORS | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | 2013-11-14 | — | — | US | claimed |
| US-20160193203-A1 | TREATMENT OF PERITONEAL INJURY USING JAK INHIBITORS | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | 2016-07-07 | — | — | US | disclosed |
| CN-105481778-A | Pyrimidine derivative, preparation method and applications thereof | SHENZHEN CHIPSCREEN BIOSCIENCES LTD | 2016-04-13 | — | — | CN | disclosed |
| CN-105399686-A | Pyrimidine derivative, preparation method and applications thereof | SHENZHEN CHIPSCREEN BIOSCIENCES LTD | 2016-03-16 | — | — | CN | disclosed |
| CN-105399685-A | Preparation method and applications of aromatic heterocyclic compound adopted as selective JAK3 and/or JAK1 kinase inhibitor | SHENZHEN CHIPSCREEN BIOSCIENCES LTD | 2016-03-16 | — | — | CN | disclosed |
| US-9198900-B2 | Treatment of peritoneal injury using JAK inhibitors | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) | 2015-12-01 | — | — | US | disclosed |
| CN-103059019-B | Imidazoles [4,5-c] pyridine-7-carboxamides derivatives, its method for making and medicinal use | HEFEI YIGONG MEDICINE CO., LTD. (CN) | 2015-11-04 | — | — | CN | disclosed |
| US-20130303563-A1 | TREATMENT OF PERITONEAL INJURY USING JAK INHIBITORS | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | 2013-11-14 | — | — | US | disclosed |
| CN-101228162-A | 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators | ASTRAZENECA AB (SE) | 2008-07-23 | — | — | CN | disclosed |
| CN-1255404-C | Process for preparing substituted imidazopyridine compounds | ASTRAZENECA AB (SE) | 2006-05-10 | — | — | CN | disclosed |
| CN-1452621-A | Process for preparing substd. imidazopyridine compound | ASTRAZENECA AB (SE) | 2003-10-29 | — | — | CN | disclosed |