Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.47 |
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11858938 | 0.84 | GPR84 (0.68) | GPR84DAO | |
| SCHEMBL17206126 | 0.80 | GPR84 (0.73) | SMN1; SMN2GPR84 | |
| SCHEMBL1287276 | 0.79 | SMN1; SMN2 (0.69) | SMN1; SMN2ADORA1GPR84DAOPARP1 | |
| Dimethylamine SCHEMBL27691701 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2ADORA1GPR84DAOPARP1 | |
| SCHEMBL6613866 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2ADORA1GPR84DAOPARP1 | |
| Benzylthiouracil SCHEMBL815137 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2ADORA1GPR84DAOPARP1 | |
| SCHEMBL28487811 | 0.76 | KMT2A (0.43) | SMN1; SMN2ADORA1DAOPARP1CYP1A2 | |
| SCHEMBL9286770 | 0.75 | PARP1 (0.51) | SMN1; SMN2ADORA1DAOPARP1CAPN1 | |
| SCHEMBL28747205 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2GPR84DAOPARP1CAPN1 | |
| SCHEMBL27893019 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2ADORA1DAOPOLBIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104039956-A | Method of treatment | GLAXOSMITHKLINE IP NO 2 LTD | 2014-09-10 | — | — | CN | disclosed |
| CN-102970869-B | Indoles | GLAXOSMITHKLINE LLC | 2014-07-16 | — | — | CN | disclosed |
| WO-2013067300-A1 | METHOD OF TREATMENT | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2013-05-10 | — | — | WO | disclosed |
| WO-2013067302-A1 | METHOD OF TREATMENT | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED (GB) | 2013-05-10 | — | — | WO | disclosed |
| CN-102970869-A | Indoles | GLAXOSMITHKLINE LLC | 2013-03-13 | — | — | CN | disclosed |