Benzylthiouracil

Benzylthiouracil

SCHEMBL815137

O=c1cc(Cc2ccccc2)[nH]c(=S)[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 1.00
CYB5R3 P00387 3/20 0.59
ALDH1A1 P00352 2/20 0.59
CYP3A4 P08684 1/20 0.59
TAS2R38 P59533 2/20 0.51
CYP2C19 P33261 2/20 0.51
LPO P22079 2/20 0.51
MPO P05164 1/20 0.51
TPO P07202 1/20 0.51
TSHR P16473 1/20 0.51
MAPT P10636 1/20 0.50
KMT2A Q03164 1/20 0.47
CYP2C9 P11712 1/20 0.46
HPGD P15428 1/20 0.46
DAO P14920 1/20 0.46
PARP1 P09874 1/20 0.45
GPR84 Q9NQS5 1/20 0.42
ADORA1 P30542 1/20 0.42
POLB P06746 1/20 0.42
PTGS1 P23219 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1287276 0.81 SMN1; SMN2 (0.69) SMN1; SMN2ALDH1A1DAOPARP1GPR84
SCHEMBL14123294 0.81 SMN1; SMN2 (0.68) SMN1; SMN2CYB5R3ALDH1A1CYP3A4TAS2R38
SCHEMBL9878921 0.80 SMN1; SMN2 (0.67) SMN1; SMN2CYB5R3ALDH1A1CYP3A4TAS2R38
Dimethylamine SCHEMBL27691701 0.77 SMN1; SMN2 (0.63) SMN1; SMN2ALDH1A1DAOPARP1GPR84
SCHEMBL14917577 0.76 SMN1; SMN2 (0.62) SMN1; SMN2ALDH1A1CYP2C19DAOPARP1
SCHEMBL5907178 0.76 SMN1; SMN2 (0.61) SMN1; SMN2CYB5R3ALDH1A1CYP3A4TAS2R38
SCHEMBL14123256 0.76 SMN1; SMN2 (0.60) SMN1; SMN2CYB5R3ALDH1A1CYP3A4TAS2R38
SCHEMBL17206126 0.75 GPR84 (0.73) SMN1; SMN2GPR84
SCHEMBL30069796 0.74 SMN1; SMN2 (0.59) SMN1; SMN2CYB5R3ALDH1A1CYP3A4TAS2R38
SCHEMBL26440143 0.74 SMN1; SMN2 (0.59) SMN1; SMN2CYB5R3ALDH1A1CYP3A4TAS2R38

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240293441-A1 NEW THERAPEUTIC USE OF TYPE 2 IODOTHYRONINE DEIODINASE (D2) INHIBITORS CHEIRONTECH S.R.L. (IT) 2024-09-05 US claimed
EP-4346841-A1 NEW THERAPEUTIC USE OF TYPE 2 IODOTHYRONINE DEIODINASE (D2) INHIBITORS Dompé Farmaceutici S.p.A. (IT) 2024-04-10 EP claimed
CN-117320730-A Novel therapeutic uses of inhibitors of type 2 iodinated thyronine deiodinase (D2) 谢龙科技有限公司 2023-12-29 CN claimed
WO-2022253729-A1 NEW THERAPEUTIC USE OF TYPE 2 IODOTHYRONINE DEIODINASE (D2) INHIBITORS MATERIAS S.R.L. (IT) 2022-12-08 WO claimed
US-20240293441-A1 NEW THERAPEUTIC USE OF TYPE 2 IODOTHYRONINE DEIODINASE (D2) INHIBITORS CHEIRONTECH S.R.L. (IT) 2024-09-05 US disclosed
EP-4346841-A1 NEW THERAPEUTIC USE OF TYPE 2 IODOTHYRONINE DEIODINASE (D2) INHIBITORS Dompé Farmaceutici S.p.A. (IT) 2024-04-10 EP disclosed
CN-117320730-A Novel therapeutic uses of inhibitors of type 2 iodinated thyronine deiodinase (D2) 谢龙科技有限公司 2023-12-29 CN disclosed
WO-2022253729-A1 NEW THERAPEUTIC USE OF TYPE 2 IODOTHYRONINE DEIODINASE (D2) INHIBITORS MATERIAS S.R.L. (IT) 2022-12-08 WO disclosed
CN-108409635-B Carbazole fluorescent thymine drug labeling reagent, synthesis and application 曲阜师范大学 2021-06-18 CN disclosed
CN-110545850-A Releasable conjugates QUIAPEG PHARMACEUTICALS AB 2019-12-06 CN disclosed
WO-2016142486-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF ANTI-ANGIOGENIC RESISTANT CANCER INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL) (ES) 2016-09-15 WO disclosed
US-20140296399-A1 PROCESS FOR PRODUCTION OF POLYLACTIC ACID RESIN COMPOSITION KAO CORP (JP) 2014-10-02 US disclosed
EP-1717267-A1 Resin composition and molded product obtained therefrom SONY CORPORATION (JP) 2006-11-02 EP disclosed
US-20060247340-A1 RESIN COMPOSITION AND MOLDED PRODUCT OBTAINED THEREFROM SONY CORPORATION (JP) 2006-11-02 US disclosed
EP-0287128-A1 Antitumor agent RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1988-10-19 EP disclosed
US-4684728-A Solubilizing biologically active compounds with reactive hydrogen atoms BAYER AKTIENGESELLSCHAFT (DE) 1987-08-04 US disclosed
EP-0017772-B1 METHOD OF IMPROVING THE SOLUBILITY OF BIOLOGICALLY ACTIVE AGENTS IN WATER AND IN LOWER ALIPHATIC ALCOHOLS, AND COMPOUNDS HAVING AN IMPROVED SOLUBILITY BAYER AG (DE) 1982-07-28 EP disclosed
EP-0014263-B1 METHOD OF IMPROVING THE SOLUBILITY OF BIOLOGICALLY ACTIVE AGENTS IN WATER AND IN LOWER ALIPHATIC ALCOHOLS, AND COMPOUNDS HAVING AN IMPROVED SOLUBILITY BAYER AG (DE) 1982-05-05 EP disclosed
EP-0017772-A1 Method of improving the solubility of biologically active agents in water and in lower aliphatic alcohols, and compounds having an improved solubility BAYER AG (DE) 1980-10-29 EP disclosed
EP-0014263-A2 Method of improving the solubility of biologically active agents in water and in lower aliphatic alcohols, and compounds having an improved solubility BAYER AG (DE) 1980-08-20 EP disclosed