Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788997 | 0.91 | EPHX2 (0.36) | EPHX2EPHX1CACNA1BKDM4ERAB9A | |
| SCHEMBL7615575 | 0.85 | KMT2A (0.41) | EPHX2SIGMAR1RAB9A | |
| SCHEMBL7615570 | 0.85 | KMT2A (0.41) | EPHX2SIGMAR1RAB9A | |
| SCHEMBL7615580 | 0.85 | KMT2A (0.41) | EPHX2SIGMAR1RAB9A | |
| SCHEMBL2597299 | 0.81 | EPHX1 (0.53) | EPHX2EPHX1RAB9AHPGD | |
| SCHEMBL15114600 | 0.75 | FPR2 (0.41) | EPHX2EPHX1SIGMAR1KDM4E | |
| SCHEMBL8806885 | 0.74 | KMT2A (0.43) | EPHX2EPHX1SIGMAR1KDM4ERAB9A | |
| SCHEMBL8559580 | 0.74 | HPGD (0.52) | TSHRHPGD | |
| SCHEMBL21597919 | 0.74 | HDAC3 (0.50) | EPHX2EPHX1HPGD | |
| SCHEMBL789907 | 0.72 | EPHX1 (0.55) | EPHX2EPHX1KDM4ERAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066869-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2013-05-10 | — | — | WO | disclosed |