Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7615575 | 1.00 | KMT2A (0.41) | KMT2ASMYD3SMN1; SMN2SIGMAR1LMNA | |
| SCHEMBL7615570 | 1.00 | KMT2A (0.41) | KMT2ASMYD3SMN1; SMN2SIGMAR1LMNA | |
| SCHEMBL8806885 | 0.89 | KMT2A (0.43) | KMT2ASMYD3SMN1; SMN2SIGMAR1LMNA | |
| SCHEMBL14917751 | 0.85 | EPHX2 (0.35) | SIGMAR1EPHX2RAB9A | |
| SCHEMBL27339703 | 0.79 | SMYD3 (0.42) | KMT2ASMYD3SMN1; SMN2SIGMAR1LMNA | |
| SCHEMBL27343743 | 0.77 | EPHX1 (0.48) | KMT2ASMYD3SIGMAR1LMNABLM | |
| SCHEMBL2597299 | 0.77 | EPHX1 (0.53) | KMT2AEPHX2HDAC4HDAC1RAB9A | |
| SCHEMBL15114600 | 0.75 | FPR2 (0.41) | SIGMAR1EPHX2 | |
| SCHEMBL788997 | 0.74 | EPHX2 (0.36) | EPHX2RAB9A | |
| SCHEMBL789128 | 0.72 | EPHX2 (0.35) | KMT2ASIGMAR1EPHX2HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620225-B1 | Cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2002-11-13 | — | — | EP | disclosed |
| US-5523400-A | 3-(PYRROLIDIN-3-YLIDENE=CH-),7-((2-AMINOTHIAZOL-4-YL)HYDROX -IMINOACETYLAMINO-)-3-CEPHEM DERIVATIVES; BROAD SPECTRUM ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0620225-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-10-19 | — | — | EP | disclosed |