Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918059 | 0.94 | KMT2A (0.58) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918267 | 0.93 | MEN1 (0.60) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918677 | 0.92 | MEN1 (0.59) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14917901 | 0.92 | MEN1 (0.59) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918039 | 0.92 | MEN1 (0.59) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918498 | 0.88 | HDAC6 (0.52) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918927 | 0.85 | MAPT (0.52) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918950 | 0.82 | MAPT (0.58) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14918364 | 0.81 | HDAC6 (0.52) | HDAC6HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL14917853 | 0.81 | MAPT (0.53) | HDAC6HDAC1HDAC8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |