Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918275 | 1.00 | HDAC6 (0.65) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL14918014 | 0.85 | HDAC4 (0.64) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL14918017 | 0.85 | HDAC4 (0.64) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL14918579 | 0.84 | HDAC6 (0.62) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL14918576 | 0.84 | HDAC6 (0.62) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL14918755 | 0.81 | HDAC4 (0.58) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL14918758 | 0.81 | HDAC4 (0.58) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL8275406 | 0.79 | HDAC3 (1.00) | HDAC6HDAC4HDAC1HDAC8HDAC5 | |
| SCHEMBL14918477 | 0.76 | HDAC4 (0.70) | HDAC6HDAC4HDAC8HDAC2 | |
| SCHEMBL14918266 | 0.76 | HDAC6 (0.62) | HDAC6HDAC4HDAC1HDAC8HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066831-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |