Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918382 | 0.94 | MAPT (0.54) | MAPTSMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL14918887 | 0.93 | MAPT (0.53) | MAPTSMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL14918725 | 0.92 | MAPT (0.52) | MAPTSMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL14918847 | 0.92 | MAPT (0.52) | MAPTSMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL14918935 | 0.92 | MAPT (0.52) | MAPTSMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL14918925 | 0.87 | MAPT (0.59) | MAPTSMN1; SMN2HTTRAB9ALMNA | |
| SCHEMBL14918927 | 0.86 | MAPT (0.52) | MAPTSMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL14918924 | 0.82 | HDAC1 (0.48) | MAPTSMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL14918404 | 0.82 | HDAC6 (0.56) | MAPTSMN1; SMN2GAALMNAGLA | |
| SCHEMBL14919092 | 0.81 | L3MBTL1 (0.55) | MAPTSMN1; SMN2HTTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |