Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918374 | 0.90 | PDK1 (0.44) | PDK1PDK2PDK3PDK4HDAC6 | |
| SCHEMBL14918961 | 0.87 | PDK1 (0.47) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL14918459 | 0.87 | HDAC6 (0.48) | PDK1PDK2PDK3PDK4HDAC6 | |
| SCHEMBL14918896 | 0.83 | MEN1 (0.41) | HDAC6HDAC4HDAC1HDAC8LMNA | |
| SCHEMBL14918873 | 0.83 | HDAC1 (0.48) | HDAC6HDAC4HDAC1HDAC8SMN1; SMN2 | |
| SCHEMBL14918237 | 0.83 | KDM4E (0.44) | HDAC6HDAC1HDAC8LMNASMN1; SMN2 | |
| SCHEMBL14918426 | 0.82 | HDAC1 (0.50) | HDAC6HDAC4HDAC1HDAC8SMN1; SMN2 | |
| SCHEMBL14918491 | 0.82 | HDAC1 (0.50) | HDAC6HDAC4HDAC1HDAC8SMN1; SMN2 | |
| SCHEMBL14918432 | 0.82 | HDAC8 (0.45) | HDAC6HDAC4HDAC1HDAC8LMNA | |
| SCHEMBL14918928 | 0.80 | HDAC4 (0.45) | HDAC6HDAC4HDAC1HDAC8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |