Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.39 |
| ▸ | CNR1 | P21554 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL587878 | 0.83 | GUCY1A1 (0.41) | PLK1 | |
| SCHEMBL13885733 | 0.82 | CNR2 (0.51) | CNR2CNR1 | |
| SCHEMBL6114329 | 0.80 | SLC9A1 (0.45) | CNR2CNR1HSD17B10KDM4ETSHR | |
| SCHEMBL13690656 | 0.78 | KDM4E (0.39) | CNR2CNR1HSD17B10KDM4ETSHR | |
| SCHEMBL4050608 | 0.77 | CNR1 (0.52) | CNR2CNR1HSD17B10KDM4ETSHR | |
| SCHEMBL593602 | 0.77 | LMNA (0.46) | CNR2HSD17B10KDM4ETSHRSLC6A4 | |
| SCHEMBL592810 | 0.76 | SCN5A (0.37) | CNR2HSD17B10KDM4ETSHRCAMK2D | |
| SCHEMBL1493630 | 0.75 | AURKA (0.40) | CNR2CNR1KDM4EHDAC1HDAC6 | |
| SCHEMBL1493643 | 0.74 | CNR2 (0.48) | CNR2CNR1HDAC1HDAC6 | |
| SCHEMBL4051371 | 0.74 | CNR1 (0.51) | CNR2CNR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033225-A2 | SUBSTITUTED 3-AMINO-CINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-24 | — | — | WO | disclosed |