Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SOD1 | P00441 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209243 | 0.72 | CYP2C19 (0.34) | NPSR1 | |
| SCHEMBL3669479 | 0.65 | NPSR1 (0.39) | NPSR1MAPTALDH1A1L3MBTL1SOD1 | |
| SCHEMBL230257 | 0.65 | NPSR1 (0.43) | NPSR1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL31202933 | 0.64 | NPSR1 (0.35) | NPSR1MAPT | |
| SCHEMBL2833742 | 0.64 | CYP3A4 (0.44) | NPSR1MAPTALDH1A1L3MBTL1SOD1 | |
| SCHEMBL20054732 | 0.63 | CYP3A4 (0.50) | NPSR1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL210214 | 0.62 | CES2 (0.36) | MAPTALDH1A1KDM4E | |
| SCHEMBL27797953 | 0.62 | MAPT (0.36) | NPSR1MAPT | |
| SCHEMBL27948270 | 0.62 | HSD11B1 (0.33) | MAPTALDH1A1L3MBTL1 | |
| SCHEMBL2453128 | 0.62 | NPSR1 (0.41) | NPSR1MAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773609-A2 | NICOTINIC RECEPTOR NON-COMPETITIVE MODULATORS | Targacept, Inc. (US) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013067105-A2 | NICOTINIC RECEPTOR NON-COMPETITIVE MODULATORS | TARGACEPT, INC. (US) | 2013-05-10 | — | — | WO | disclosed |