Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919146 | 1.00 | MAPT (0.51) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL6615901 | 0.92 | RAB9A (0.53) | GAAMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL6615905 | 0.92 | RAB9A (0.53) | GAAMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL1654194 | 0.89 | KDM4A (0.46) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL21410824 | 0.89 | ALDH1A1 (0.53) | MAPTGAAMEN1KMT2ATDP1 | |
| SCHEMBL21410822 | 0.89 | ALDH1A1 (0.53) | MAPTGAAMEN1KMT2ATDP1 | |
| SCHEMBL14933701 | 0.86 | MAPK1 (0.49) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL5582439 | 0.81 | MEN1 (0.54) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL5582440 | 0.81 | MEN1 (0.54) | MAPTGAAMEN1KMT2AMAPK1 | |
| SCHEMBL28447871 | 0.81 | MME (0.52) | MAPTMEN1KMT2AMMEPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066838-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |