Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919475 | 1.00 | MAPT (0.67) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL3964158 | 0.88 | MAPT (0.70) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL3964168 | 0.88 | MAPT (0.70) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL16952973 | 0.83 | TUBB4A (0.52) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30268627 | 0.81 | ALDH1A1 (0.64) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1159451 | 0.81 | ALDH1A1 (0.64) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2296673 | 0.80 | MEN1 (0.58) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2296668 | 0.80 | MEN1 (0.58) | MAPTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL309988 | 0.80 | TRPA1 (0.53) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14932382 | 0.80 | TUBB4A (0.52) | MAPTMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122036715-A | 2, 4-Diarylaminopyrimidine derivative containing benzodithioryl, and pharmaceutical composition and application thereof | 盐城工业职业技术学院 | 2026-05-15 | — | — | CN | disclosed |
| CN-118047779-B | Dihydropteridinone derivatives containing benzobisheteroaryl and use thereof | 沈阳药科大学 | 2025-02-11 | — | — | CN | disclosed |
| CN-118047779-A | Dihydropteridinone derivatives containing benzobisheteroaryl and use thereof | 沈阳药科大学 | 2024-05-17 | — | — | CN | disclosed |
| WO-2024099226-A1 | BIPHENYL HETEROARYL-CONTAINING DIHYDROPTERIDINONE DERIVATIVE, AND USE THEREOF | 沈阳药科大学 | 2024-05-16 | — | — | WO | disclosed |
| US-9096582-B2 | Gamma secretase modulators | MERCK SHARP & DOHME CORP (US) | 2015-08-04 | — | — | US | disclosed |
| US-9096582-B2 | Gamma secretase modulators | MERCK SHARP & DOHME CORP (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140296311-A1 | GAMMA SECRETASE MODULATORS | MERCK SHARP & DOHME LLC | 2014-10-02 | — | — | US | disclosed |
| US-20140296311-A1 | GAMMA SECRETASE MODULATORS | MERCK SHARP & DOHME LLC | 2014-10-02 | — | — | US | disclosed |
| EP-2773202-A1 | GAMMA SECRETASE MODULATORS | Merck Sharp & Dohme Corp. (US) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013066740-A1 | GAMMA SECRETASE MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2013-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296311-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | MAPT 83/4885MEN1 3320/4885KMT2A 3860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.