⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2486250 | 0.75 | HTR2A (0.31) | — | |
| SCHEMBL11276656 | 0.74 | ALDH1A1 (0.37) | — | |
| SCHEMBL11281110 | 0.74 | HRH3 (0.39) | — | |
| SCHEMBL11370488 | 0.74 | MAPT (0.36) | — | |
| SCHEMBL11362552 | 0.69 | MAPT (0.43) | — | |
| SCHEMBL5150725 | 0.67 | KEAP1 (0.41) | — | |
| SCHEMBL1491958 | 0.67 | PARP1 (0.34) | — | |
| SCHEMBL11347765 | 0.66 | HTR2C (0.31) | — | |
| SCHEMBL11318566 | 0.64 | BRD4 (0.35) | — | |
| SCHEMBL7588373 | 0.62 | HTR1A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109897051-A | A kind of preparation method of 3- oxa- -8- aza-bicyclo [3,2,1] octane hydrochloride | 白银乐天园化学有限责任公司 | 2019-06-18 | — | — | CN | claimed |
| US-20190247371-A1 | METHODS FOR TREATING SMALL CELL LUNG CANCERS BY USING PHARMACEUTICAL COMPOSITIONS OR COMBINATIONS COMPRISING INDOLIZINO[6,7-B]INDOLE DERIVATIVES | ACADEMIA SINICA (TW) | 2019-08-15 | — | — | US | disclosed |
| EP-3515437-A1 | METHODS FOR TREATING SMALL CELL LUNG CANCERS BY USING PHARMACEUTICAL COMPOSITIONS OR COMBINATIONS COMPRISING INDOLIZINO (6,7-B) INDOLE DERIVATIVES | Academia Sinica (TW) | 2019-07-31 | — | — | EP | disclosed |
| CN-109897051-A | A kind of preparation method of 3- oxa- -8- aza-bicyclo [3,2,1] octane hydrochloride | 白银乐天园化学有限责任公司 | 2019-06-18 | — | — | CN | disclosed |
| CN-109897051-A | A kind of preparation method of 3- oxa- -8- aza-bicyclo [3,2,1] octane hydrochloride | 白银乐天园化学有限责任公司 | 2019-06-18 | — | — | CN | disclosed |
| WO-2018057712-A1 | METHODS FOR TREATING SMALL CELL LUNG CANCERS BY USING PHARMACEUTICAL COMPOSITIONS OR COMBINATIONS COMPRISING INDOLIZINO (6,7-B) INDOLE DERIVATIVES | ACADEMIA SINICA (TW) | 2018-03-29 | — | — | WO | disclosed |
| EP-1954838-B1 | CODED MOLECULES FOR DETECTING TARGET ANALYTES | LIFE TECHNOLOGIES CORP (US) | 2014-02-26 | — | — | EP | disclosed |
| US-20110086395-A1 | NOVEL MICROORGANISM AND ITS USE IN LIGNOCELLULOSE DETOXIFICATION | SHELL OIL COMPANY | 2011-04-14 | — | — | US | disclosed |
| EP-2308959-A1 | Novel microorganism and its use in lignocellulose detoxifixcation | Shell Internationale Research Maatschappij B.V. (NL) | 2011-04-13 | — | — | EP | disclosed |
| WO-2011026906-A2 | NOVEL MICROORGANISM AND ITS USE IN LIGNOCELLULOSE DETOXIFICATION | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 2011-03-10 | — | — | WO | disclosed |
| WO-2007120265-A2 | CODED MOLECULES FOR DETECTING TARGET ANALYTES | APPLERA CORPORATION (US) | 2007-10-25 | — | — | WO | disclosed |
| US-20070190543-A1 | Coded Molecules for Detecting Target Analytes | APPLERA CORPORATION (US) | 2007-08-16 | — | — | US | disclosed |
| US-6100392-A | Electron-deficient porphyrins and processes and intermediates for preparing same | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLAVANIA (US) | 2000-08-08 | — | — | US | disclosed |
| EP-0757690-A4 | ELECTRON-DEFICIENT PORPHYRINS AND PROCESSES AND INTERMEDIATES FOR PREPARING SAME | UNIV PENNSYLVANIA (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5856515-A | Electron-deficient porphyrins and processes and intermediates for preparing same | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-01-05 | — | — | US | disclosed |
| EP-0757690-A1 | ELECTRON-DEFICIENT PORPHYRINS AND PROCESSES AND INTERMEDIATES FOR PREPARING SAME | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1997-02-12 | — | — | EP | disclosed |
| US-5599924-A | Electron-deficient porphyrins and processes and intermediates for preparing same | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1995029916-A1 | ELECTRON-DEFICIENT PORPHYRINS AND PROCESSES AND INTERMEDIATES FOR PREPARING SAME | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1995-11-09 | — | — | WO | disclosed |
| US-4647576-A | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1987-03-03 | — | — | US | disclosed |
| EP-0179559-A2 | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1986-04-30 | — | — | EP | disclosed |