Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919803 | 0.86 | POLB (0.67) | ALDH1A1MAPTPOLBHTTLMNA | |
| SCHEMBL14919509 | 0.84 | KMT2A (0.65) | ALDH1A1MAPTPOLBHTTLMNA | |
| SCHEMBL14919916 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTPOLBLMNAKDM4E | |
| SCHEMBL14919481 | 0.81 | POLB (0.68) | ALDH1A1MAPTPOLBKDM4EHPGD | |
| SCHEMBL14919801 | 0.79 | POLB (0.59) | ALDH1A1MAPTPOLBLMNAKDM4E | |
| SCHEMBL14920008 | 0.79 | POLB (0.64) | ALDH1A1MAPTPOLBKDM4EHPGD | |
| SCHEMBL22422345 | 0.79 | TP53 (1.00) | ALDH1A1MAPTPOLBHTTTP53 | |
| SCHEMBL14919610 | 0.79 | ALDH1A1 (0.78) | ALDH1A1MAPTPOLBLMNAKDM4E | |
| SCHEMBL14919795 | 0.78 | POLB (0.58) | ALDH1A1MAPTPOLBLMNAKDM4E | |
| SCHEMBL14919833 | 0.77 | TSHR (0.60) | ALDH1A1MAPTPOLBLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066469-A2 | KINASE INHIBITORS CAPABLE OF INCREASING THE SENSITIVITY OF BACTERIAL PATHOGENS TO B-LACTAM ANTIBIOTICS | SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2013-05-10 | — | — | WO | disclosed |