Malic Acid

Malic Acid

SCHEMBL14920139

O=C(O)CC(=O)O.O=C(O)CC(O)C(=O)O.[NaH].[NaH]

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F

The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.79
LDHA P00338 1/20 0.47
SRR Q9GZT4 1/20 0.47
TET2 Q6N021 6/20 0.46
TET3 O43151 2/20 0.46
TET1 Q8NFU7 1/20 0.46
SLC22A6 Q4U2R8 1/20 0.46
KDM4A O75164 2/20 0.44
KDM4C Q9H3R0 2/20 0.44
KDM2A Q9Y2K7 2/20 0.44
OR51E2 Q9H255 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
GABRR1 P24046 2/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Malic Acid SCHEMBL177314 0.97 SMN1; SMN2 (0.83) SMN1; SMN2LDHASRRTET2TET3
Malic Acid SCHEMBL14990328 0.95 SMN1; SMN2 (0.79) SMN1; SMN2LDHASRRTET2TET3
Malic Acid SCHEMBL28831630 0.92 SMN1; SMN2 (0.94) SMN1; SMN2TET2TET3TET1SLC22A6
Malic Acid SCHEMBL3408016 0.92 SMN1; SMN2 (0.94) SMN1; SMN2TET2TET3TET1SLC22A6
Malic Acid SCHEMBL123090 0.92 SMN1; SMN2 (0.94) SMN1; SMN2TET2TET3TET1SLC22A6
Malic Acid SCHEMBL637799 0.92 SMN1; SMN2 (0.94) SMN1; SMN2TET2TET3TET1SLC22A6
Malic Acid SCHEMBL3408017 0.92 SMN1; SMN2 (0.94) SMN1; SMN2TET2TET3TET1SLC22A6
Malic Acid SCHEMBL16783985 0.90 SMN1; SMN2 (0.71) SMN1; SMN2LDHASRRTET2TET3
Malic Acid SCHEMBL16150600 0.89 SMN1; SMN2 (0.88) SMN1; SMN2TET2TET3TET1SLC22A6
Malic Acid SCHEMBL7573228 0.89 SMN1; SMN2 (0.88) SMN1; SMN2TET2TET3TET1SLC22A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3201306-A1 ANTIMICROBIAL CLEANSING COMPOSITION Unilever NV (NL) 2017-08-09 EP disclosed
WO-2016050493-A1 ANTIMICROBIAL CLEANSING COMPOSITION UNILEVER N.V. (NL) 2016-04-07 WO disclosed
EP-2780438-A1 A LIQUID HARD SURFACE ANTIMICROBIAL CLEANING COMPOSITION Unilever N.V. (NL) 2014-09-24 EP disclosed
EP-2773315-A2 A PERSONAL CLEANING COMPOSITION Unilever N.V. (NL) 2014-09-10 EP disclosed
EP-2773739-A1 A LIQUID HARD SURFACE ANTIMICROBIAL CLEANING COMPOSITION Unilever N.V. (NL) 2014-09-10 EP disclosed
WO-2013064360-A2 A PERSONAL CLEANING COMPOSITION UNILEVER N.V. (NL) 2013-05-10 WO disclosed
WO-2013064315-A1 A LIQUID HARD SURFACE ANTIMICROBIAL CLEANING COMPOSITION UNILEVER N.V. (NL) 2013-05-10 WO disclosed
WO-2013064340-A1 A LIQUID HARD SURFACE ANTIMICROBIAL CLEANING COMPOSITION UNILEVER N.V. (NL) 2013-05-10 WO disclosed