Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.83 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.50 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.48 |
| ▸ | TET3 | O43151 | 2/20 | 0.48 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | KDM4A | O75164 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL14920139 | 0.97 | SMN1; SMN2 (0.79) | SMN1; SMN2LDHASRRTET2TET3 | |
| Malic Acid SCHEMBL14990328 | 0.97 | SMN1; SMN2 (0.79) | SMN1; SMN2LDHASRRTET2TET3 | |
| Malic Acid SCHEMBL16783985 | 0.93 | SMN1; SMN2 (0.71) | SMN1; SMN2LDHASRRTET2TET3 | |
| Malic Acid SCHEMBL31673494 | 0.91 | — | — | |
| Malic Acid SCHEMBL89131 | 0.91 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| Malic Acid SCHEMBL31673489 | 0.91 | — | — | |
| Malic Acid SCHEMBL256122 | 0.91 | — | — | |
| Malic Acid SCHEMBL98496 | 0.91 | — | — | |
| Malic Acid SCHEMBL30036864 | 0.91 | — | — | |
| Malic Acid SCHEMBL856 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116438295-A | Methods and compositions for culturing pluripotent cell suspensions | 生命技术公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2021215852-A1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY AND TREATMENT METHOD USING SAME COMPOSITION | (주)셀트리온 (KR) | 2021-10-28 | — | — | WO | disclosed |
| CN-104540902-B | Light polymerization process, ink group, image forming method, ink composite and the Photoepolymerizationinitiater initiater used in them and water-soluble union II imidazoles | 富士胶片株式会社 | 2018-04-24 | — | — | CN | disclosed |
| CN-105334283-B | Simultaneous Determination reconstituted tobacco oxalate, amber acid radical, the sample-pretreating method of sulfate radical and phosphate radical | 广东中烟工业有限责任公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105372371-A | Ion chromatography method for simultaneous determination of oxalic ion, succinate ion, sulfate ion and phosphate ion in reconstituted tobacco and application thereof | CHINA TOBACCO GUANGDONG IND CO | 2016-03-02 | — | — | CN | disclosed |
| CN-105334283-A | Sample pretreatment method for simultaneous determination of oxalic acid, succinic acid, sulfuric acid and phosphate radicals in regenerated tobacco leaves through ion chromatography | CHINA TOBACCO GUANGDONG IND CO | 2016-02-17 | — | — | CN | disclosed |
| EP-2571837-A1 | PROCESSES FOR PRODUCING NH4+ -OOC-R-COOH COMPOUNDS FROM FERMENTATION BROTHS CONTAINING NH4+ -OOC-R-COO-NH4+COMPOUNDS AND/OR HOOC-R-COOH COMPOUND ACIDS, AND CONVERSION OF NH4+ -OOC-R-COOH COMPOUNDS TO HOOC-R-COOH COMPOUND ACIDS | Bioamber, S.A.S. (FR) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011136944-A1 | PROCESSES FOR PRODUCING NH4 + -OOC-R-COOH COMPOUNDS FROM FERMENTATION BROTHS CONTAINING NH4 + -OOC-R-COO-NH4 +COMPOUNDS AND/OR HOOC-R-COOH COMPOUND ACIDS, AND CONVERSION OF NH4 + -OOC-R-COOH COMPOUNDS TO HOOC-R-COOH COMPOUND ACIDS | BIOAMBER S,A.S. (CA) | 2011-11-03 | — | — | WO | disclosed |
| EP-2344487-A1 | HEPATITIS C INHIBITOR COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2011-07-20 | — | — | EP | disclosed |
| EP-2235173-A2 | POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME | Novozymes A/S (DK) | 2010-10-06 | — | — | EP | disclosed |
| WO-2010034105-A1 | HEPATITIS C INHIBITOR COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009085935-A2 | POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME | NOVOZYMES A/S (DK) | 2009-07-09 | — | — | WO | disclosed |