Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ANPEP | P15144 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 4/20 | 0.49 |
| ▸ | MMP3 | P08254 | 4/20 | 0.49 |
| ▸ | MMP2 | P08253 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14920623 | 0.82 | TSHR (0.64) | TSHRANPEP | |
| SCHEMBL17873232 | 0.82 | LDHA (0.59) | ALDH1A1F2RL1SMN1; SMN2HTTMMP3 | |
| SCHEMBL8256096 | 0.80 | TSHR (1.00) | TSHRALDH1A1SMN1; SMN2HTTANPEP | |
| SCHEMBL5616235 | 0.80 | KDM4E (0.62) | TSHRALDH1A1HTTMMP1MMP3 | |
| SCHEMBL7277594 | 0.76 | HTT (0.56) | ALDH1A1F2RL1SMN1; SMN2HTT | |
| SCHEMBL25306507 | 0.75 | ALDH1A1 (0.72) | ALDH1A1F2RL1SMN1; SMN2HTTGAA | |
| SCHEMBL28126646 | 0.75 | LDHA (0.68) | ALDH1A1F2RL1SMN1; SMN2HTT | |
| SCHEMBL2238188 | 0.74 | HTT (0.59) | ALDH1A1F2RL1SMN1; SMN2HTT | |
| SCHEMBL2942342 | 0.74 | HTT (0.59) | ALDH1A1F2RL1SMN1; SMN2HTT | |
| SCHEMBL8837562 | 0.74 | HTT (0.51) | ALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788326-A1 | N-(PYRID-4-YL)AMIDES AND N-(PYRIMIDIN-4-YL)AMIDES AND THEIR PHARMACEUTICAL AND COSMETIC USE | Galderma Research & Development (FR) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013064681-A1 | N-(PYRID-4-YL)AMIDES AND N-(PYRIMIDIN-4-YL)AMIDES AND THEIR PHARMACEUTICAL AND COSMETIC USE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-05-10 | — | — | WO | disclosed |