Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14920505 | 0.82 | TSHR (0.56) | LMNAMAPK1NLRP1P2RX7SMN1; SMN2 | |
| SCHEMBL18887747 | 0.82 | LMNA (0.57) | LMNAMAPK1NLRP1P2RX7SMN1; SMN2 | |
| SCHEMBL1143411 | 0.78 | LMNA (0.53) | LMNAMAPK1NLRP1P2RX7SMN1; SMN2 | |
| SCHEMBL6649593 | 0.77 | HTT (0.69) | LMNAMAPK1NLRP1P2RX7SMN1; SMN2 | |
| SCHEMBL2748481 | 0.74 | LMNA (0.52) | LMNAMAPK1NLRP1P2RX7SMN1; SMN2 | |
| SCHEMBL10900021 | 0.74 | ALDH1A1 (0.59) | LMNAMAPK1NLRP1P2RX7ALDH1A1 | |
| SCHEMBL28706018 | 0.73 | KCNH2 (0.52) | LMNAMAPK1NLRP1P2RX7ALDH1A1 | |
| SCHEMBL17914676 | 0.73 | ALDH1A1 (0.62) | LMNAMAPK1NLRP1P2RX7ALDH1A1 | |
| SCHEMBL9114275 | 0.73 | MAPT (0.51) | LMNAMAPK1L3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9112200 | 0.73 | MAPT (0.51) | LMNAMAPK1L3MBTL1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773644-A1 | AZETIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013064467-A1 | AZETIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-10 | — | — | WO | disclosed |