Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19308468 | 0.89 | KCNB1 (0.56) | SORT1KCNK3KCNK9KCNB1CNR1 | |
| SCHEMBL16596227 | 0.84 | HSD17B10 (0.52) | SORT1KCNK3KCNK9KCNB1CNR1 | |
| SCHEMBL13036336 | 0.81 | SORT1 (0.52) | SORT1KCNK3KCNK9CNR1HDAC4 | |
| SCHEMBL15880285 | 0.81 | SORT1 (0.55) | SORT1KCNK3KCNK9CNR1HDAC4 | |
| SCHEMBL30846618 | 0.80 | IDO1 (0.46) | SORT1KCNK3KCNK9KCNB1HDAC4 | |
| SCHEMBL30930477 | 0.80 | SORT1 (0.51) | SORT1KCNK3KCNK9CNR1HDAC4 | |
| SCHEMBL20310370 | 0.80 | SORT1 (0.51) | SORT1KCNK3KCNK9CNR1HDAC4 | |
| SCHEMBL19116521 | 0.79 | MTNR1B (0.52) | SORT1KCNK3KCNK9KMT2AALDH1A1 | |
| SCHEMBL19111001 | 0.77 | AAK1 (0.50) | SORT1KCNK3KCNK9KCNB1CNR1 | |
| SCHEMBL19151039 | 0.77 | KMT2A (0.53) | SORT1KCNK3KCNK9CNR1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788326-A1 | N-(PYRID-4-YL)AMIDES AND N-(PYRIMIDIN-4-YL)AMIDES AND THEIR PHARMACEUTICAL AND COSMETIC USE | Galderma Research & Development (FR) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013064681-A1 | N-(PYRID-4-YL)AMIDES AND N-(PYRIMIDIN-4-YL)AMIDES AND THEIR PHARMACEUTICAL AND COSMETIC USE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-05-10 | — | — | WO | disclosed |