Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664691 | 0.98 | EPHX1 (0.33) | EPHX1KEAP1NFE2L2ALOX5SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3952769 | 0.89 | SMN1; SMN2 (0.31) | SMN1; SMN2 | |
| SCHEMBL8020012 | 0.82 | EPHX1 (0.33) | EPHX1ALOX5SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL28057200 | 0.79 | KEAP1 (0.39) | EPHX1KEAP1NFE2L2MEN1ALDH1A1 | |
| SCHEMBL9800626 | 0.76 | RECQL (0.35) | EPHX1KEAP1NFE2L2SMN1; SMN2ALDH1A1 | |
| SCHEMBL28714523 | 0.76 | ALDH1A1 (0.34) | EPHX1KEAP1NFE2L2ALOX5SMN1; SMN2 | |
| SCHEMBL27576640 | 0.75 | SMN1; SMN2 (0.33) | EPHX1ALOX5SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL5197125 | 0.75 | EPHX1 (0.38) | EPHX1ALOX5SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8958254 | 0.73 | GRM2 (0.38) | EPHX1ALOX5SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8958248 | 0.73 | GRM2 (0.38) | EPHX1ALOX5SMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788326-A1 | N-(PYRID-4-YL)AMIDES AND N-(PYRIMIDIN-4-YL)AMIDES AND THEIR PHARMACEUTICAL AND COSMETIC USE | Galderma Research & Development (FR) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013064681-A1 | N-(PYRID-4-YL)AMIDES AND N-(PYRIMIDIN-4-YL)AMIDES AND THEIR PHARMACEUTICAL AND COSMETIC USE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2013-05-10 | — | — | WO | disclosed |