Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14922267 | 0.83 | ADRB1 (0.49) | HRH3MAPTKCNH2ALDH1A1SIGMAR1 | |
| SCHEMBL14922313 | 0.82 | HRH3 (0.57) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL14922311 | 0.81 | HRH3 (0.56) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL8275460 | 0.79 | HRH3 (0.59) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL16218812 | 0.79 | DRD2 (0.59) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL22022308 | 0.77 | HRH3 (0.61) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL21659428 | 0.76 | HRH3 (0.68) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL8363114 | 0.76 | HRH3 (0.63) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL18875805 | 0.76 | HRH3 (0.52) | HRH3MAPTHPGDTSHRTAAR1 | |
| SCHEMBL14922299 | 0.75 | HRH3 (0.56) | HRH3MAPTHPGDTSHRTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44205-E1 | Adenosine A2a receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-05-07 | — | — | US | disclosed |
| US-RE44205-E1 | Adenosine A2a receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2013-05-07 | — | — | US | disclosed |