Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30302255 | 1.00 | AR (0.54) | ARCYP1A2HSD17B10ALDH1A1KMT2A | |
| SCHEMBL20439669 | 0.83 | ALDH1A1 (0.61) | ARCYP1A2HSD17B10ALDH1A1KMT2A | |
| SCHEMBL23727631 | 0.81 | KDM4E (0.51) | ARCYP1A2HSD17B10ALDH1A1KMT2A | |
| SCHEMBL23727633 | 0.81 | KDM4E (0.51) | ARCYP1A2HSD17B10ALDH1A1KMT2A | |
| SCHEMBL27273810 | 0.80 | ESR1 (0.46) | CYP1A2HSD17B10ALDH1A1KDM4EGAA | |
| SCHEMBL30970390 | 0.80 | ESR1 (0.46) | CYP1A2HSD17B10ALDH1A1KDM4EGAA | |
| SCHEMBL6111999 | 0.80 | KDM4E (0.54) | ARCYP1A2HSD17B10ALDH1A1KMT2A | |
| SCHEMBL7308321 | 0.80 | KDM4E (0.54) | ARCYP1A2HSD17B10ALDH1A1KMT2A | |
| SCHEMBL30968144 | 0.80 | KDM4E (0.54) | ARCYP1A2HSD17B10ALDH1A1KMT2A | |
| SCHEMBL24162249 | 0.79 | ALDH1A1 (0.46) | ARALDH1A1KDM4EGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024521-B2 | Isoquinoline derivatives, methods of synthesis and uses thereof | PROSETTA BIOSCIENCES, INC. (US) | 2024-07-02 | — | — | US | disclosed |
| US-12024521-B2 | Isoquinoline derivatives, methods of synthesis and uses thereof | PROSETTA BIOSCIENCES, INC. (US) | 2024-07-02 | — | — | US | disclosed |
| WO-2022006228-A1 | ISOQUINOLINE DERIVATIVES, METHODS OF SYNTHESIS AND USES THEREOF | PROSETTA BIOSCIENCES, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| US-20210403477-A1 | Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof | PROSETTA BIOSCIENCES, INC. | 2021-12-30 | — | — | US | disclosed |
| WO-2018140876-A1 | NRF2 ACTIVATOR | BIOGEN MA INC. (US) | 2018-08-02 | — | — | WO | disclosed |
| US-8436013-B2 | Compounds and methods for treatment of alpha-1 antitrypsin deficiency | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12024521-B2 | Isoquinoline derivatives, methods of synthesis and uses thereof | POLRMT, MAVS, SYNCRIP | AR 4522/4885CYP1A2 1270/4885HSD17B10 2988/4885 |
| US-20210403477-A1 | Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof | POLRMT, MAVS, SYNCRIP | AR 4522/4885CYP1A2 1270/4885HSD17B10 2988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.