Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 2/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661077 | 0.75 | TDP1 (0.55) | KDM4EL3MBTL1ALDH1A1LMNANPSR1 | |
| SCHEMBL1102422 | 0.75 | TDP1 (0.55) | KDM4EL3MBTL1ALDH1A1LMNANPSR1 | |
| SCHEMBL3584983 | 0.75 | KMT2A (0.50) | KDM4EL3MBTL1ALDH1A1LMNANPSR1 | |
| SCHEMBL29280829 | 0.73 | HSD17B10 (0.47) | KDM4EALDH1A1LMNATDP1SMN1; SMN2 | |
| SCHEMBL24702664 | 0.73 | TDP1 (0.56) | KDM4EL3MBTL1ALDH1A1LMNANPSR1 | |
| SCHEMBL732131 | 0.70 | KDM4E (0.74) | KDM4EL3MBTL1ALDH1A1LMNANPSR1 | |
| SCHEMBL29382173 | 0.70 | KDM4E (0.74) | KDM4EL3MBTL1ALDH1A1LMNANPSR1 | |
| SCHEMBL461448 | 0.70 | IDO1 (0.47) | KDM4ELMNANPSR1SMN1; SMN2KMT2A | |
| SCHEMBL9097250 | 0.69 | SMN1; SMN2 (0.50) | ALDH1A1NPSR1SMN1; SMN2MLKL | |
| SCHEMBL7735370 | 0.68 | KDM4E (0.65) | KDM4EL3MBTL1ALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061764-B1 | HETEROCYCLIC DERIVATIVES BINDING TO THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR (PBR) | TECHNION RES & DEV FOUNDATION (IL) | 2014-07-02 | — | — | EP | disclosed |
| EP-2589597-A2 | Heterocyclic derivatives binding to the peripheral-type benzodiazepine receptor (PBR) | Technion Research & Development Foundation (IL) | 2013-05-08 | — | — | EP | disclosed |