Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1102422 | 0.88 | TDP1 (0.55) | TDP1KDM4EPKML3MBTL1ALDH1A1 | |
| SCHEMBL24702664 | 0.85 | TDP1 (0.56) | TDP1KDM4EPKML3MBTL1ALDH1A1 | |
| SCHEMBL732131 | 0.78 | KDM4E (0.74) | TDP1KDM4EPKML3MBTL1ALDH1A1 | |
| SCHEMBL29382173 | 0.78 | KDM4E (0.74) | TDP1KDM4EPKML3MBTL1ALDH1A1 | |
| SCHEMBL23776295 | 0.77 | TDP1 (0.43) | TDP1KDM4EPKML3MBTL1ALDH1A1 | |
| SCHEMBL3584983 | 0.76 | KMT2A (0.50) | TDP1KDM4EPKML3MBTL1ALDH1A1 | |
| SCHEMBL8020858 | 0.76 | MAPK14 (0.54) | TDP1KDM4EPKMALDH1A1KMT2A | |
| SCHEMBL14923045 | 0.75 | KDM4E (0.50) | TDP1KDM4EPKML3MBTL1ALDH1A1 | |
| SCHEMBL865711 | 0.75 | KDM4E (0.71) | TDP1KDM4EPKML3MBTL1ALDH1A1 | |
| SCHEMBL28710728 | 0.75 | KDM4E (0.71) | TDP1KDM4EPKML3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231641-A2 | QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009081105-A2 | QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-07-02 | — | — | WO | disclosed |