Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 4/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2311389 | 0.73 | DAO (0.45) | MAOBHSD17B10MAPTALDH1A1KDM4E | |
| SCHEMBL891520 | 0.72 | MAOB (0.53) | MAOBHSD17B10MAPTESR2ALDH1A1 | |
| SCHEMBL14365712 | 0.72 | NPC1 (0.41) | HSD17B10MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL24747270 | 0.71 | POLB (0.56) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14028247 | 0.71 | HTR1A (0.48) | MAPTALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL8886041 | 0.71 | ATM (0.50) | MAOBHSD17B10MAPTESR2ALDH1A1 | |
| SCHEMBL8884813 | 0.71 | MAOB (0.61) | MAOBHSD17B10MAPTESR2ALDH1A1 | |
| SCHEMBL8883187 | 0.70 | OPRM1 (0.54) | HSD17B10MAPTESR2ALDH1A1PGR | |
| SCHEMBL8885801 | 0.70 | HSD17B10 (0.47) | MAOBHSD17B10MAPTESR2ALDH1A1 | |
| SCHEMBL8885180 | 0.70 | HSD17B10 (0.44) | MAOBHSD17B10MAPTESR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004182-B1 | BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXO GROUP LTD (GB) | 2013-05-08 | — | — | EP | disclosed |