Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520594 | 0.91 | LMNA (0.48) | LMNAMEN1KMT2AL3MBTL1HSD11B1 | |
| SCHEMBL7529419 | 0.84 | LMNA (0.59) | LMNAMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL7522027 | 0.83 | LMNA (0.46) | LMNAKDM2BMEN1KMT2AHSD11B1 | |
| SCHEMBL7523356 | 0.83 | MGLL (0.47) | LMNAKDM2BMEN1KMT2AHSD11B1 | |
| SCHEMBL7520759 | 0.83 | LMNA (0.49) | LMNAMEN1KMT2AL3MBTL1HSD11B1 | |
| SCHEMBL7522191 | 0.82 | POLB (0.44) | LMNAHSD11B1ALDH1A1MGLL | |
| SCHEMBL7524523 | 0.81 | LMNA (0.45) | LMNAMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL7519944 | 0.80 | ACHE (0.42) | KMT2AL3MBTL1ALDH1A1TSHR | |
| SCHEMBL7526647 | 0.79 | MEN1 (0.42) | MEN1KMT2AL3MBTL1HSD11B1ALDH1A1 | |
| SCHEMBL7523784 | 0.78 | HTT (0.45) | LMNAKDM2BMEN1KMT2AMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699455-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-05-08 | — | — | EP | disclosed |