Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 7/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22803712 | 0.88 | RORC (0.43) | RORCSYKDGAT1MAPKAPK2EGLN2 | |
| SCHEMBL30412966 | 0.82 | SYK (0.39) | RORCSYKDGAT1MAPKAPK2EGLN2 | |
| SCHEMBL29813612 | 0.80 | SYK (0.45) | RORCSYKMAPKAPK2EGLN2NAMPT | |
| SCHEMBL15081332 | 0.80 | SYK (0.45) | RORCSYKMAPKAPK2EGLN2NAMPT | |
| SCHEMBL30004261 | 0.79 | SYK (0.44) | RORCSYKMAPKAPK2EGLN2NAMPT | |
| SCHEMBL2015768 | 0.79 | SYK (0.44) | RORCSYKMAPKAPK2EGLN2NAMPT | |
| SCHEMBL25898751 | 0.79 | SYK (0.44) | RORCSYKMAPKAPK2EGLN2NAMPT | |
| SCHEMBL29509761 | 0.79 | SYK (0.44) | RORCSYKMAPKAPK2EGLN2NAMPT | |
| SCHEMBL29178680 | 0.79 | SYK (0.44) | RORCSYKMAPKAPK2EGLN2NAMPT | |
| SCHEMBL23147868 | 0.77 | SYK (0.43) | RORCSYKMAPKAPK2EGLN2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895585-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8895585-B2 | Nicotinamide derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8809371-B2 | — | — | 2014-08-19 | — | — | US | disclosed |
| US-8809371-B2 | — | — | 2014-08-19 | — | — | US | disclosed |
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2013-05-09 | — | — | US | disclosed |
| EP-2589592-A1 | NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF | FUJIFILM Corporation (JP) | 2013-05-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116430-A1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | SYK, CD38, BTK | RORC 492/4885SYK 1/4885DGAT1 2937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.