Etofylline

Etofylline

SCHEMBL149271

Cn1c(=O)c2c(ncn2CCO)n(C)c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ADORA2B P29275 10/20 1.00
LMNA P02545 3/20 1.00
MAPT P10636 1/20 0.72
PDE4A P27815 1/20 0.72
PDE4B Q07343 1/20 0.72
PDE4C Q08493 1/20 0.72
PDE4D Q08499 1/20 0.72
SMN1; SMN2 Q16637 3/20 0.68
POLB P06746 1/20 0.68
MAPK1 P28482 1/20 0.66
RXFP1 Q9HBX9 1/20 0.66
ALDH1A1 P00352 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9293406 0.91 ADORA2B (0.83) ADORA2BLMNAMAPTPDE4APDE4B
SCHEMBL16120984 0.90 ADORA2B (0.81) ADORA2BLMNAMAPTSMN1; SMN2POLB
SCHEMBL8697228 0.89 ADORA2B (0.81) ADORA2BLMNAMAPTPDE4APDE4B
SCHEMBL4650753 0.89 ADORA2B (0.79) ADORA2BLMNAMAPTSMN1; SMN2POLB
SCHEMBL9293800 0.88 ADORA2B (0.78) ADORA2BLMNAMAPTPDE4APDE4B
SCHEMBL9293922 0.88 ADORA2B (0.78) ADORA2BLMNAMAPTPDE4APDE4B
SCHEMBL9294488 0.88 ADORA2B (0.78) ADORA2BLMNAMAPTPDE4APDE4B
SCHEMBL8070551 0.88 ADORA2B (0.78) ADORA2BLMNAMAPTPDE4APDE4B
SCHEMBL10856641 0.88 ADORA2B (0.78) ADORA2BLMNAMAPTPDE4APDE4B
SCHEMBL10652746 0.88 ADORA2B (0.78) ADORA2BLMNAMAPTPDE4APDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1395 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119595784-A Method for detecting related substances of aminophylline injection 山东玉满坤生物科技有限公司 2025-03-11 CN claimed
CN-117999073-A Use of nadolol to treat chronic obstructive pulmonary disease by blocking the inhibitor protein-2 pathway 慢性呼吸道治疗有限公司 2024-05-07 CN claimed
CN-117169380-A Aminophylline and method for detecting related substances or/and content of injection thereof 湖南尔康制药股份有限公司 2023-12-05 CN claimed
US-20230008367-A1 COMPOUNDS USEFUL FOR TREATING LIVER DISEASES ABIONYX PHARMA SA (FR) 2023-01-12 US claimed
EP-4034236-A1 COMPOUNDS USEFUL FOR TREATING LIVER DISEASES Abionyx Pharma SA (FR) 2022-08-03 EP claimed
CN-114732842-A Lightyellow sophora root extract with anti-tumor activity and quality detection method and application thereof 南京中医药大学 2022-07-12 CN claimed
CN-114558059-A Radix sophorae flavescentis-coptis chinensis extract with anti-tumor activity and quality detection method and application thereof 南京中医药大学 2022-05-31 CN claimed
CN-114555614-A Anti-cancer compounds as non-PGP substrates 深圳艾欣达伟医药科技有限公司 2022-05-27 CN claimed
CN-114223448-A Planting method for phyllostachys pubescens 湖南绿地高新农林开发有限公司 2022-03-25 CN claimed
WO-2021059023-A1 COMPOUNDS USEFUL FOR TREATING LIVER DISEASES ABIONYX PHARMA SA (FR) 2021-04-01 WO claimed
US-5151273-A Time release tablets or dragees made from hemicelluloses, adjuvants of a copolymer of hydroxybutyric acid and hydroxyvaleric acid LENZING AKTIENGESELLSCHAFT (AT) 1992-09-29 US claimed
EP-0488345-A1 1,4-Dihydropyridine derivatives and methods of producing the same FUJIREBIO INC. (JP) 1992-06-03 EP claimed
EP-0480934-A1 A SLIMMING PHARMACEUTICAL COMPOSITION. DAK LAB AS (DK) 1992-04-22 EP claimed
WO-1991000730-A1 A SLIMMING PHARMACEUTICAL COMPOSITION DAK-LABORATORIET A/S (DK) 1991-01-24 WO claimed
US-4902516-A WITH COATING OF POLY-3-HYDROXYBUTYROLACTONE; DRUG DELIVERY CHEMIE HOLDING AKTIENGESELLSCHAFT (AT) 1990-02-20 US claimed
US-4844910-A CONTROLLED RELEASE OF THEOPHYLLINE DERIVATIVES EUROCELTIQUE, S.A. (LU) 1989-07-04 US claimed
EP-0270305-A2 Spheroids Euroceltique S.A. (LU) 1988-06-08 EP claimed
EP-0191624-A2 Gold-purine antitumor agents ENGELHARD CORPORATION (US) 1986-08-20 EP claimed
US-4606920-A ETOFYLLINE, VITAMIN A, AND MAGNESIUM COMPOUND WALTER HANS PETER (DE) 1986-08-19 US claimed
EP-0059974-B1 PROCESS FOR THE PREPARATION OF PHENOXYALCANECARBONIC-ACID ESTERS OF HYDROXYETHYL THEOPHYLINE Ludwig Merckle GmbH & Co. chem.-pharm. Fabrik (DE) 1985-07-31 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230008367-A1 COMPOUNDS USEFUL FOR TREATING LIVER DISEASES SLC10A1, CPT1A, CES1 ADORA2B 1780/4885LMNA 2355/4885MAPT 1742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.